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Bhat S, Vasi Z, Jiang L, Selvaraj S, Ferguson R, Gudur A, Ismai H, Adhikari R, Dhabaria A, Ueberheide B and Kuchay S.

Geranylgeranylated-SCFFBXO10 Regulates Selective Outer Mitochondrial Membrane Proteostasis and Function

BioRxiv, April 17, 2024.


Liang D, Jiang L, Bhat S, Missiroli S, Perrone M, Lauriola A, Adhikari R, Gudur A, Vasi Z, Ahearn I, Guardavaccaro D, Giorgi C, Philips M and Kuchay S.

Palmitoylation and PDE6δ Regulate Membrane-compartment Specific Substrate Ubiquitylation and Degradation.

Cell Reports, Jan 31;42(1):111999, 2023.

Bhat SA, Ferguson R, Adhikari R, and Kuchay S.

Detection of membrane-anchoring lipid modifications of proteins in cells by radioactive metabolic labeling.

STAR Protocols, Sep 15;4(3):102416, 2023.

Bhat SA, Vasi Z, Adhikari R, Gudur A, Ali A, Jiang L, Ferguson R, Liang D, Kuchay S.

Ubiquitin Proteasome System in Immune Regulation and Therapeutics.

Curr Opin Pharmacol, 67:10231, 2022.

Kuchay S., Wang H., Homer H., Marzio A., Jain K., Homer H., Fehrenbacher N., Philips MR., Zheng N., and Pagano M.

GGTase3 is a Newly Identified Geranylgeranyltransferase Targeting a Ubiquitin Ligase.

Nat Struct Mol Biol 26: 628-636, 2019. (see also Editor's Choice Highlight)

Kuchay S., Saeed M., Giorgi C., Li J., Hoffmann H., Pinton P., Rice C., and Pagano M.

NS5A promotes constitutive degradation of IP3R3 to counteract apoptosis induced by hepatitis C virus.

Cell Reports 24(5): 833-840, 2018.

Kuchay S., Giorgi C., Simoneschi D., Pagan J., Missiroli S., et al.

PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumor growth. 

Nature 546:554-558, 2017. (see also News & Views and News & thoughts)

Kuchay S., Duan S., Schenkein E., Peschiaroli A., Saraf A., Florens L. Washburn MP., Pagano M.

FBXL2- and PTPL1-mediated and PTPL1- mediated degradation of p85β controls PI3K activity.
Nature Cell Biol 15: 472-480, 2013.

Kuchay SM., Wieschhaus AJ., Marinkovic M., Herman IM., Chishti AH.

Targeted gene inactivation reveals a functional role of Calpain-1 in platelet spreading.

J of Thrombosis and Haemostasis 10(6): 1120–32, 2012.


Kuchay SM., Kim N., Grunz EA., Fay WP., Chishti AH.

Double Knockouts Reveal that Protein Tyrosine Phosphatase 1B Is a Physiological Target of Calpain-1 in Platelets

Molecular and Cellular Biology 27 (17): 6038-6052, 2007.

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