Bhat S, Vasi Z, Jiang L, Selvaraj S, Ferguson R, Salvarvand S, Gudur A, Adhikari R, Castillo V, Ismai H, Dhabaria A, Ueberheide B and Kuchay S.
Geranylgeranylated-SCFFBXO10 Regulates Selective Outer Mitochondrial Membrane Proteostasis and Function.
Cell Reports, Oct 22;43, 114783, 2024.​
Liang D, Jiang L, Bhat S, Missiroli S, Perrone M, Lauriola A, Adhikari R, Gudur A, Vasi Z, Ahearn I, Guardavaccaro D, Giorgi C, Philips M and Kuchay S.
Palmitoylation and PDE6δ Regulate Membrane-compartment Specific Substrate Ubiquitylation and Degradation.
Cell Reports, Jan 31;42(1):111999, 2023.
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Bhat SA, Ferguson R, Adhikari R, and Kuchay S.
Detection of membrane-anchoring lipid modifications of proteins in cells by radioactive metabolic labeling.
STAR Protocols, Sep 15;4(3):102416, 2023.
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Bhat SA, Vasi Z, Adhikari R, Gudur A, Ali A, Jiang L, Ferguson R, Liang D, Kuchay S.
Ubiquitin Proteasome System in Immune Regulation and Therapeutics.
Curr Opin Pharmacol, 67:10231, 2022.​
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Kuchay S., Wang H., Homer H., Marzio A., Jain K., Homer H., Fehrenbacher N., Philips MR., Zheng N., and Pagano M.
GGTase3 is a Newly Identified Geranylgeranyltransferase Targeting a Ubiquitin Ligase.
Nat Struct Mol Biol 26: 628-636, 2019. (see also Editor's Choice Highlight)
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Kuchay S., Saeed M., Giorgi C., Li J., Hoffmann H., Pinton P., Rice C., and Pagano M.
NS5A promotes constitutive degradation of IP3R3 to counteract apoptosis induced by hepatitis C virus.
Cell Reports 24(5): 833-840, 2018.
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Kuchay S., Giorgi C., Simoneschi D., Pagan J., Missiroli S., et al.
PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumor growth.
Nature 546:554-558, 2017. (see also News & Views and News & thoughts)
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Kuchay S., Duan S., Schenkein E., Peschiaroli A., Saraf A., Florens L. Washburn MP., Pagano M.
FBXL2- and PTPL1-mediated and PTPL1- mediated degradation of p85β controls PI3K activity.
Nature Cell Biol 15: 472-480, 2013.
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Kuchay SM., Wieschhaus AJ., Marinkovic M., Herman IM., Chishti AH.
Targeted gene inactivation reveals a functional role of Calpain-1 in platelet spreading.
J of Thrombosis and Haemostasis 10(6): 1120–32, 2012.
Kuchay SM., Kim N., Grunz EA., Fay WP., Chishti AH.
Double Knockouts Reveal that Protein Tyrosine Phosphatase 1B Is a Physiological Target of Calpain-1 in Platelets
