We are systematically investigating mechanisms governing ubiquitin-regulated pathways operating at cellular membrane compartments using unbiased and interdisciplinary approaches. We seek to uncover the functional involvement of these pathways in disease, cancer in particular.
​
Although protein degradation by the ubiquitin proteasome system in general is well studied, its role in regulating membrane proteins remains somewhat enigmatic. To offer important new insights into the biology of membrane protein turnover, we are focusing on identifying novel ubiquitin-regulated pathways operating at cellular membranes and understanding their dysregulation in disease.