Welcome to Our Lab!
Understanding the molecular mechanisms of deregulated cancer cell survival and proliferation is fundamental to the targeted molecular therapy and rational drug discovery. We are systematically investigating, with unbiased and interdisciplinary approaches, the mechanisms of ubiquitin regulated pathways operating at cell membranes. We seek to uncover the functional involvement of these pathways in disease, cancer in particular.
Currently, we are focused on:
(1) Characterization of ubiquitin regulated pathways at cellular membranes, and the underlying molecular mechanisms of compartmentalized substrate degradation.
(2) Characterization and functional studies of GGTase 3, a newly identified prenyltransferase that targets E3 ubiquitin ligases.
GFP-FBXL2 trafficking to cellular membranes